@USBR selects three submissions to receive prizes for the eradication of invasive mussels in open water prize competition

Quaggas on sandal at Lake Mead

Here’s the release from the Bureau of Reclamation (Peter Soeth):

Bureau of Reclamation Commissioner Brenda Burman announced today that Reclamation has selected three submissions for its prize competition seeking ideas to eradicate mussels in open water. Steven Suhr and Marie-Claude Senut will receive a full award of $80,000 for their idea while Wen Chen and Absar Alum with Stephanie Bone will each receive $10,000.

“Providing water managers with new tools to control invasive quagga and zebra mussels is an important part of protecting infrastructure and ecosystems,” Commissioner Burman said. “Reclamation is committed to working with our partners to prevent the spread of quagga and zebra mussels in the West.”

The prize competition was a theoretical challenge and sought innovative solutions to eradicate invasive quagga and zebra mussels from large reservoirs, lakes and rivers in a cost-effective and environmentally sound manner. Invasive mussel infestations pose a significant logistical and economic challenge for local communities, recreationists and water managers. There is no practical method available today for the large-scale control of invasive dreissenid mussel population once they become established.

Steven Suhr and Marie-Claude Senut, founders of Biomilab, LLC, proposed using genomic modification to induce a lethal malignant hemic neoplasia in mussels that can be transferred from one mussel to another by proximity. They suggested utilizing the CRISPR/cas9-mediated genome modification to target the function or expression of endogenous dreissenid mussel p53 or telomerase reverse transcriptase genes, or to introduce the viral SV40 Tag gene. This submission for the prize competition received $80,000.

Wen Chen, a research scientist at Harvard Medical School, proposed utilizing single stranded DNA/RNA oligonucleotide-based aptamers to target the modified amino acid 3,4 dihydroxyphenylalanine (DOPA) or dreissenid specific foot proteins to interrupt attachment, eventually leading to mussel mortality. The use of aptamers to target DOPA and foot proteins to interrupt mussel settlement is a novel idea and received $10,000.

Absar Alum of BioDetek with Stephanie Bone proposed genome modification to develop male mussels that produce sperm containing a light triggered optogenetic switch to drive upregulation or downregulation of cyclin-b expression resulting in death of the fertilized egg. This strategy relies on sunlight penetration into the upper portions of a water body to turn on the optogenetic switch in free-floating, transparent developing eggs and embryos. It was found to be a novel idea and received $10,000.

A total of 238 solvers signed up to solve this challenge and more than 100 solvers submitted solutions. Of those solutions submitted, 67 were deemed viable and were judged. Reclamation collaborated with the U.S. Geological Survey, the U.S. Army Corps of Engineers, and Molloy & Associates on this prize competition. To learn more about this prize competition please visit https://www.usbr.gov/research/challenges/mussels.html.

The results of this prize competition will support a broader effort by the federal government, as well as work by the Western Governors’ Association, western states, and tribes to protect western ecosystems, water infrastructure and hydroelectric facilities from invasive mussels. To learn more, please visit https://www.usbr.gov/mussels.

CRISPR-Cas9 is a method of genome editing that exploits a natural DNA-snipping enzyme in bacteria, called Cas9 (CRISPR-associated protein 9) to target and edit particular genes. CRISPR stands for Clustered regularly interspaced short palindromic repeats, which are segments of DNA of a particular structure found widely in bacteria and archaea (prokaryotes). In the wild, the CRISPR-Cas9 system is part of the prokaryotic immune system, which can snip out of the genome DNA acquired from foreign sources such as phages (bacterial viruses). The same molecular machinery is now being used to enable genetic material to be cut from and pasted into the genomes of other organisms, including eukaryotes such as humans. It might offer a tool for curing genetically based diseases. Graphic via Cambridge University

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